hPDI: a database of experimental human protein-DNA interactions

Bioinformatics. 2010 Jan 15;26(2):287-9. doi: 10.1093/bioinformatics/btp631. Epub 2009 Nov 9.


The human protein DNA Interactome (hPDI) database holds experimental protein-DNA interaction data for humans identified by protein microarray assays. The unique characteristics of hPDI are that it contains consensus DNA-binding sequences not only for nearly 500 human transcription factors but also for >500 unconventional DNA-binding proteins, which are completely uncharacterized previously. Users can browse, search and download a subset or the entire data via a web interface. This database is freely accessible for any academic purposes.

Availability: http://bioinfo.wilmer.jhu.edu/PDI/.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / metabolism
  • Databases, Protein
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Protein Interaction Mapping / methods
  • Software*


  • DNA-Binding Proteins
  • DNA