Activation of alpha-latrotoxin receptors in neuromuscular synapses leads to a prolonged splash acetylcholine release

Bull Exp Biol Med. 2009 Jun;147(6):701-3. doi: 10.1007/s10517-009-0600-5.


The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant alpha-latrotoxin (LT(N4C)) were analyzed. In contrast to wild-type alpha-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LT(N4C) causes only splash release lasting over many hours. Thus, activation of alpha-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / metabolism*
  • Animals
  • Electrophysiology
  • Exocytosis
  • Mice
  • Mutation
  • Receptors, Peptide / metabolism*
  • Receptors, Peptide / physiology*
  • Spider Venoms / genetics
  • Spider Venoms / metabolism
  • Synapses / metabolism*


  • Receptors, Peptide
  • Spider Venoms
  • alpha-latrotoxin receptor
  • alpha-latrotoxin
  • Acetylcholine