Effect of afobazole on mitochondrial monoamine oxidase A activity in vitro

Bull Exp Biol Med. 2009 Jul;148(1):23-5. doi: 10.1007/s10517-009-0630-z.

Abstract

Selective anxiolytic afobazole (1 mM) inhibits monoamine oxidase A activity in mitochondria from rat brain and liver (IC(50) 0.36 and 0.43, respectively). Effect of the compound does not depend on the time of preincubation with mitochondria. Triple washout of mitochondria is followed by complete recovery of initial enzyme activity.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Benzimidazoles / pharmacology*
  • Brain / drug effects*
  • Brain / enzymology
  • Liver / drug effects*
  • Liver / enzymology
  • Mitochondria / drug effects*
  • Mitochondria / enzymology
  • Monoamine Oxidase / drug effects*
  • Morpholines / pharmacology*
  • Rats

Substances

  • 2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole
  • Anti-Anxiety Agents
  • Benzimidazoles
  • Morpholines
  • Monoamine Oxidase