Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report

Eur J Pediatr. 2010 Jun;169(6):763-5. doi: 10.1007/s00431-009-1095-9. Epub 2009 Nov 10.


Neonatal acute adrenal insufficiency (AAI) is a rare but severe condition. We report a case of AAI following maternal exposure to moderate doses of corticosteroids during pregnancy. The neonate, born at term, presented with hypoglycaemia complicated by seizures. The AAI was confirmed by endocrine tests and after exclusion of differential diagnoses. Early diagnosis and treatment led to full recovery.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adrenal Insufficiency / chemically induced*
  • Adult
  • Anti-Inflammatory Agents / adverse effects*
  • Female
  • Humans
  • Hypoglycemia / chemically induced*
  • Infant, Newborn
  • Male
  • Prednisone / adverse effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Seizures / chemically induced*


  • Anti-Inflammatory Agents
  • Prednisone