Endosomal leakage and nuclear translocation of multiwalled carbon nanotubes: developing a model for cell uptake

Nano Lett. 2009 Dec;9(12):4370-5. doi: 10.1021/nl902647x.

Abstract

We report our findings on cellular membrane penetration, endocytosis, endosomal leakage, and nuclear translocation of multiwalled carbon nanotubes (MWCNTs). Our data is consistent with a working model for MWCNTs' cell uptake and cellular translocations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus / physiology*
  • Cell Line
  • Endocytosis / physiology*
  • Endosomes / physiology*
  • Humans
  • Kidney / physiology*
  • Models, Biological*
  • Nanotubes, Carbon*

Substances

  • Nanotubes, Carbon