Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Apr;21(2):215-23.
doi: 10.1111/j.1600-0838.2009.01044.x.

Myostatin Expression During Human Muscle Hypertrophy and Subsequent Atrophy: Increased Myostatin With Detraining

Affiliations

Myostatin Expression During Human Muscle Hypertrophy and Subsequent Atrophy: Increased Myostatin With Detraining

J G Jespersen et al. Scand J Med Sci Sports. .

Abstract

Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were obtained from young male subjects before and after 30 and 90 days of resistance training as well as after 3, 10, 30, 60 and 90 days of subsequent detraining. Myostatin mRNA increased significantly with detraining. We observed a 28 kDa myostatin immunoreactive protein, which, however, was also present in myostatin knock out mice skeletal muscle. As a novel finding we consistently detected a 10 kDa band, which may represent a mature myostatin monomer under reducing conditions or a novel, unknown myostatin form. Further, we observed a significant increase in this 10 kDa band after 3 days of detraining preceding the rapid type II fiber atrophy, in which almost half of the acquired fiber area was lost after only 10 days of detraining. Accordingly, an increase in the level of the 10 kDa protein is associated with rapid type II fiber atrophy, suggesting myostatin-mediated specific type II fiber atrophy, which in combination with our mRNA data support a role for myostatin in the negative regulation of adult human skeletal muscle mass.

Similar articles

See all similar articles

Cited by 19 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback