Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer

Br J Cancer. 2009 Dec 15;101(12):1957-60. doi: 10.1038/sj.bjc.6605414. Epub 2009 Nov 10.


Background: Recently, the vitamin D receptor (VDR) polymorphism FokI was shown to be associated with susceptibility to ovarian cancer. We aimed to examine whether VDR FokI polymorphisms influence the survivals of patients with epithelial ovarian cancer (EOC).

Methods: VDR polymorphisms from FokI in 101 patients with EOC were genotyped by sequencing. Overall survival was compared between FokI single nucleotide polymorphism using Kaplan-Meier survival curves with log-rank tests and the Cox proportional hazard model adjusted for ages, stages, histology, and existence of residual tumour.

Results: The FokI C/C genotypes were associated with better prognosis compared with the C/T and T/T genotypes (log-rank test: P = 0.008; adjusted hazard ratio, 0.18; 95%CI 0.05-0.61; P = 0.006).

Conclusions: These results suggest that the VDR polymorphisms from the FokI genotype may be associated with improved prognosis of patients with EOC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Deoxyribonucleases, Type II Site-Specific / metabolism
  • Female
  • Genotype
  • Humans
  • Middle Aged
  • Neoplasms, Glandular and Epithelial / genetics*
  • Neoplasms, Glandular and Epithelial / mortality
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / mortality
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • Proportional Hazards Models
  • Receptors, Calcitriol / genetics*
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood


  • Receptors, Calcitriol
  • Vitamin D
  • 25-hydroxyvitamin D
  • endodeoxyribonuclease FokI
  • Deoxyribonucleases, Type II Site-Specific