Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Chem Commun (Camb). 2009 Dec 7;(45):7033-5. doi: 10.1039/b909666c. Epub 2009 Oct 13.


C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacterial Proteins / metabolism
  • Carbon-Sulfur Lyases / metabolism
  • Drug Agonism
  • Homoserine / analogs & derivatives*
  • Homoserine / chemical synthesis
  • Homoserine / chemistry
  • Lactones / chemical synthesis
  • Lactones / chemistry*
  • Luminescent Measurements
  • Vibrio / chemistry*


  • Bacterial Proteins
  • Lactones
  • N-octanoylhomoserine lactone
  • Homoserine
  • Carbon-Sulfur Lyases
  • LuxS protein, Bacteria