Hedgehog signalling: Kif7 is not that fishy after all

Curr Biol. 2009 Sep 15;19(17):R729-31. doi: 10.1016/j.cub.2009.07.060.

Abstract

Recent reports examining the mammalian kinesin relative Kif7 highlight the conserved role for microtubule motor proteins in Drosophila and vertebrate Hedgehog signalling. Mammalian Kif7 action centres at the primary cilium, an organelle absent from Drosophila. These studies raise interesting questions about the coupling of microtubule trafficking to the Hedgehog pathway.

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Patterning
  • Drosophila / metabolism
  • Drosophila Proteins / physiology
  • Hedgehog Proteins / metabolism*
  • Kinesin / physiology*
  • Mice
  • Signal Transduction*

Substances

  • Drosophila Proteins
  • Hedgehog Proteins
  • cos protein, Drosophila
  • Kif7 protein, mouse
  • Kinesin