Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes

Nucleic Acids Res. 2010 Jan;38(Database issue):D670-5. doi: 10.1093/nar/gkp957. Epub 2009 Nov 11.

Abstract

The Network of Cancer Genes (NCG) collects and integrates data on 736 human genes that are mutated in various types of cancer. For each gene, NCG provides information on duplicability, orthology, evolutionary appearance and topological properties of the encoded protein in a comprehensive version of the human protein-protein interaction network. NCG also stores information on all primary interactors of cancer proteins, thus providing a complete overview of 5357 proteins that constitute direct and indirect determinants of human cancer. With the constant delivery of results from the mutational screenings of cancer genomes, NCG represents a versatile resource for retrieving detailed information on particular cancer genes, as well as for identifying common properties of precompiled lists of cancer genes. NCG is freely available at: http://bio.ifom-ieo-campus.it/ncg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Computational Biology / trends
  • Databases, Genetic*
  • Databases, Nucleic Acid*
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Gene Regulatory Networks
  • Genes, Neoplasm*
  • Genome, Plant
  • Humans
  • Information Storage and Retrieval / methods
  • Internet
  • Mutation
  • Neoplasms / genetics*
  • Software