The immune epitope database 2.0

Nucleic Acids Res. 2010 Jan;38(Database issue):D854-62. doi: 10.1093/nar/gkp1004. Epub 2009 Nov 11.


The Immune Epitope Database (IEDB, provides a catalog of experimentally characterized B and T cell epitopes, as well as data on Major Histocompatibility Complex (MHC) binding and MHC ligand elution experiments. The database represents the molecular structures recognized by adaptive immune receptors and the experimental contexts in which these molecules were determined to be immune epitopes. Epitopes recognized in humans, nonhuman primates, rodents, pigs, cats and all other tested species are included. Both positive and negative experimental results are captured. Over the course of 4 years, the data from 180,978 experiments were curated manually from the literature, which covers approximately 99% of all publicly available information on peptide epitopes mapped in infectious agents (excluding HIV) and 93% of those mapped in allergens. In addition, data that would otherwise be unavailable to the public from 129,186 experiments were submitted directly by investigators. The curation of epitopes related to autoimmunity is expected to be completed by the end of 2010. The database can be queried by epitope structure, source organism, MHC restriction, assay type or host organism, among other criteria. The database structure, as well as its querying, browsing and reporting interfaces, was completely redesigned for the IEDB 2.0 release, which became publicly available in early 2009.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Communicable Diseases / immunology
  • Communicable Diseases / metabolism
  • Computational Biology / methods*
  • Computational Biology / trends
  • Databases, Genetic*
  • Databases, Protein
  • Epitopes / chemistry*
  • Humans
  • Immune System / physiology*
  • Immunogenetics / methods*
  • Information Storage and Retrieval / methods
  • Internet
  • Major Histocompatibility Complex
  • Peptides / chemistry
  • Proteins / chemistry
  • Software


  • Epitopes
  • Peptides
  • Proteins