Confocal Scan Features of Keratic Precipitates in Fuchs Heterochromic Iridocyclitis

Cornea. 2010 Jan;29(1):39-42. doi: 10.1097/ICO.0b013e3181acf674.

Abstract

Purpose: To characterize confocal scan features of keratic precipitates (KPs) in Fuchs heterochromic iridocyclitis.

Methods: Confocal scans of KPs in patients with Fuchs uveitis were performed. Polymerase chain reaction technique of aqueous for herpes simplex, herpes zoster, Toxoplasma, cytomegalovirus, and rubella was performed for 4 patients.

Results: Confocal scan was performed in 40 eyes of 34 patients [18 males and 16 females, mean age 30.7 +/- 10.5 years (range 18-57 years)]. Fuchs heterochromic iridocyclitis was bilateral in 6 and unilateral in 28 patients. All eyes had KPs: globular KPs were found in 34 eyes, infiltrating and dendritiform in 31 eyes, stippled in 27 eyes, and cruciform in 19 eyes. Polymerase chain reaction of aqueous specimens for the above-mentioned infectious agents was negative in 4 eyes of 4 individuals who had infiltrating and dendritiform KPs on confocal scan, with no other concurrent disorder.

Conclusions: Confocal features of KPs in Fuchs uveitis are diverse. The presence of dendritiform and infiltrating KPs on confocal scan may not be suggestive of an infectious etiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aqueous Humor / parasitology
  • Aqueous Humor / virology
  • Cornea / pathology*
  • Corneal Diseases / diagnosis*
  • Cytomegalovirus / genetics
  • Cytomegalovirus / isolation & purification
  • DNA, Protozoan / analysis
  • DNA, Viral / analysis
  • Female
  • Herpesvirus 1, Human / genetics
  • Herpesvirus 1, Human / isolation & purification
  • Herpesvirus 3, Human / genetics
  • Herpesvirus 3, Human / isolation & purification
  • Humans
  • Iridocyclitis / diagnosis*
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Polymerase Chain Reaction
  • Rubella virus / genetics
  • Rubella virus / isolation & purification
  • Toxoplasma / genetics
  • Toxoplasma / isolation & purification
  • Young Adult

Substances

  • DNA, Protozoan
  • DNA, Viral