Changes in CREB (SER133) content and DNA-binding activity of transcriptional factors in rat brain cells against the background of ladasten exposure

Bull Exp Biol Med. 2009 May;147(5):599-602. doi: 10.1007/s10517-009-0573-4.
[Article in English, Russian]

Abstract

We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adamantane / analogs & derivatives*
  • Adamantane / toxicity
  • Animals
  • Brain / drug effects*
  • Brain / metabolism*
  • Cyclic AMP Response Element-Binding Protein / metabolism*
  • DNA / metabolism*
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism
  • Male
  • Protein Binding / drug effects
  • Rats

Substances

  • Cyclic AMP Response Element-Binding Protein
  • N-(2-adamantyl)-N-p-bromophenylamine
  • DNA
  • Adamantane