Changes in CREB (SER133) content and DNA-binding activity of transcriptional factors in rat brain cells against the background of ladasten exposure
Bull Exp Biol Med. 2009 May;147(5):599-602.
doi: 10.1007/s10517-009-0573-4.
[Article in
English,
Russian]
Affiliation
- 1 Laboratory of Molecular Immunology and Pharmacology, Institute of Biochemistry and Genetics, Ufa Research Centre, Russian Academy of Sciences, Moscow, Russia. milyausha78@mail.ru
Abstract
We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
-
Adamantane / analogs & derivatives*
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Adamantane / toxicity
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Animals
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Brain / drug effects*
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Brain / metabolism*
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Cyclic AMP Response Element-Binding Protein / metabolism*
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DNA / metabolism*
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Hippocampus / drug effects
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Hippocampus / metabolism
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Hypothalamus / drug effects
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Hypothalamus / metabolism
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Male
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Protein Binding / drug effects
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Rats
Substances
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Cyclic AMP Response Element-Binding Protein
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N-(2-adamantyl)-N-p-bromophenylamine
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DNA
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Adamantane