Comparative study of immunocorrective activity of phenibut and its organic salts in experimental immunodeficiency

Bull Exp Biol Med. 2009 May;147(5):606-8. doi: 10.1007/s10517-009-0571-6.
[Article in English, Russian]

Abstract

Phenibut and its derivatives normalized cellular (index of delayed-type hypersensitivity reaction) and humoral (antierythrocyte antibody titer) immunity and the lymphoproliferative processes in immunocompetent organs of animals with cyclophosphamide-induced immunosuppression. This indicates pronounced immunocorrective effects of these substances.

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Cyclophosphamide / pharmacology
  • Female
  • Immunity, Cellular / drug effects
  • Immunity, Humoral / drug effects
  • Immunologic Deficiency Syndromes* / chemically induced
  • Immunologic Deficiency Syndromes* / drug therapy
  • Immunosuppressive Agents / pharmacology*
  • Immunosuppressive Agents / therapeutic use
  • Lymphocyte Activation / drug effects
  • Male
  • Mice
  • Mice, Inbred CBA
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Adjuvants, Immunologic
  • Immunosuppressive Agents
  • gamma-Aminobutyric Acid
  • Cyclophosphamide
  • 4-amino-3-phenylbutyric acid