Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

Cell Mol Life Sci. 2010 Jan;67(2):171-7. doi: 10.1007/s00018-009-0189-x. Epub 2009 Nov 12.

Abstract

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked growing interest in the pharmacological potential of ROCK inhibitors beyond their current application in cardiovascular disease. This article discusses the therapeutic benefits of novel ROCK inhibitors in development, and highlights the recent advances in the current understanding of disease-dependent and isoform-specific functions of ROCK and their potential impact on future therapeutic strategies.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / enzymology
  • Dogs
  • Glaucoma / drug therapy*
  • Glaucoma / enzymology
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / enzymology
  • Mice
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / enzymology
  • Protein Kinase Inhibitors / chemistry
  • Protein Kinase Inhibitors / therapeutic use*
  • Rats
  • rho-Associated Kinases / antagonists & inhibitors*
  • rho-Associated Kinases / chemistry

Substances

  • Isoenzymes
  • Protein Kinase Inhibitors
  • rho-Associated Kinases