Locked-in syndrome: A rare manifestation of pediatric stroke

Indian J Pediatr. 2009 Oct;76(10):1053-5. doi: 10.1007/s12098-009-0200-4. Epub 2009 Nov 12.

Abstract

Locked-in syndrome is characterized by upper motor neuron quadriplegia, paralysis of lower cranial nerves, bilateral horizontal gaze palsy and anarthria, with preserved consciousness. It is due to a ventral pontine lesion following a basilar artery occlusion. We report the first Indian case report of locked-in syndrome, a 10-year old girl in whom the syndome was preceded by a 'herald hemiparesis'. Although the exact etiology for the basilar artery occlusion could not be determined, treatment with low molecular weight heparin and warfarin was followed by partial recovery.

Publication types

  • Case Reports

MeSH terms

  • Arterial Occlusive Diseases / complications
  • Arterial Occlusive Diseases / diagnosis*
  • Arterial Occlusive Diseases / drug therapy
  • Basilar Artery / pathology*
  • Child
  • Female
  • Follow-Up Studies
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Humans
  • India
  • Magnetic Resonance Angiography
  • Neuropsychological Tests
  • Quadriplegia / diagnosis
  • Quadriplegia / drug therapy
  • Quadriplegia / etiology*
  • Rare Diseases
  • Recovery of Function
  • Severity of Illness Index
  • Stroke / complications
  • Stroke / diagnosis*
  • Stroke / drug therapy
  • Treatment Outcome
  • Warfarin / therapeutic use

Substances

  • Heparin, Low-Molecular-Weight
  • Warfarin