Protoxylocarpins F-H, protolimonoids from seed kernels of Xylocarpus granatum

Khanitha Pudhom; Damrong Sommit; Paulwatt Nuclear; Nattaya Ngamrojanavanich; Amorn Petsom

doi:10.1021/np900640u

Protoxylocarpins F-H, protolimonoids from seed kernels of Xylocarpus granatum

J Nat Prod. 2009 Dec;72(12):2188-91. doi: 10.1021/np900640u.

Authors

Khanitha Pudhom¹, Damrong Sommit, Paulwatt Nuclear, Nattaya Ngamrojanavanich, Amorn Petsom

Affiliation

¹ Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, 10330, Thailand. Khanitha.P@chula.ac.th

PMID: 19908853
DOI: 10.1021/np900640u

Abstract

Three new protolimonoids, protoxylocarpins F-H (1-3), along with 11 known limonoids, were isolated from seed kernels of Xylocarpus granatum. Their structures were elucidated on the basis of extensive spectroscopic data analyses. All compounds isolated were evaluated for cytotoxic activity against five human tumor cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Screening Assays, Antitumor
Humans
Limonins / chemistry
Limonins / isolation & purification*
Limonins / pharmacology
Meliaceae / chemistry*
Molecular Structure
Seeds / chemistry
Thailand

Substances

Limonins
protoxylocarpin F
protoxylocarpin G
protoxylocarpin H