Impaired insulin secretion and uptake in patients with diffuse idiopathic skeletal hyperostosis

Endocr Regul. 2009 Oct;43(4):149-55.


Objective: So far, high prevalence of metabolic symptoms accompanying diffuse idiopathic skeletal hyperostosis (DISH) appears not definitely elucidated because of their possible origin from other disorders such as diabetes and/or body mass differences. From such reasons this study was aimed to compare non-diabetic DISH patients to a group of age and BMI matched controls in order to distinguish the influence of DISH proper on metabolic parameters free of additional metabolic effects caused by diabetes and/or body weight differences.

Methods: Both groups of patients were subjected to oral glucose tolerance test (OGTT) and fasting serum levels of glucose, insulin, C-peptide, growth hormone, insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGF-BP3) were assayed. Fasting serum total cholesterol, HDL cholesterol, triglycerides, non-esterified fatty acids (NEFA) and uric acid were determined as well. The indices of insulin sensitivity and insulin secretion were calculated.

Results: With the exception of decreased NEFA serum level and decreased insulinogenic index and insulin/C-peptide ratio in DISH patients any other significant differences in serum parameters and indices of insulin sensitivity were not found.

Conclusions: The data obtained suggest impaired beta-cell pancreatic stimulation and increased insulin hepatic extraction in DISH. It is assumed that the above mentioned conditions, if persisting for a long time, might lead to decreased ability of insulin to maintain normal serum glucose level and consequently to insulin resistance which is highly prevalent in symptomatic DISH patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / analysis
  • C-Peptide / blood
  • Fatty Acids, Nonesterified / blood
  • Female
  • Glucose Tolerance Test
  • Human Growth Hormone / blood
  • Humans
  • Hyperostosis, Diffuse Idiopathic Skeletal / complications
  • Hyperostosis, Diffuse Idiopathic Skeletal / metabolism*
  • Hyperostosis, Diffuse Idiopathic Skeletal / physiopathology
  • Insulin / blood*
  • Insulin / metabolism
  • Insulin Resistance
  • Insulin Secretion
  • Insulin-Like Growth Factor Binding Protein 3 / blood
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Secreting Cells / physiology
  • Lipids / blood
  • Male
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / etiology
  • Middle Aged


  • Blood Glucose
  • C-Peptide
  • Fatty Acids, Nonesterified
  • Insulin
  • Insulin-Like Growth Factor Binding Protein 3
  • Lipids
  • Human Growth Hormone
  • Insulin-Like Growth Factor I