Timetable of effects of testosterone administration to hypogonadal men on variables of sex and mood

Aging Male. 2009 Dec;12(4):113-8. doi: 10.3109/13685530903322858.


Introduction: The effects of testosterone have been extensively characterized, but little attention has been given to the timetable of occurrence of the various effects of testosterone.

Methods: The timetables of effects on sexual and psychological variables in 40 hypogonadal men receiving treatment with either parenteral testosterone enanthate (TE) or undecanoate (TU).

Results: Sexual thoughts/fantasies and sexual interest/desire/spontaneous morning erections emerged quickly and plateaued after 3 weeks. Total erections rose to a maximum over 9 weeks and then plateaued. Ejaculations per week/satisfaction with sex life rose over the first 3 weeks, increasing steadily to a plateau at 12 weeks. Depression scores decreased to reach a plateau after 6 weeks. Aggressiveness did not change. Scores of concentration improved and reached a plateau after 3 weeks in the group treated with TE and after 9 weeks in the group treated with TU. Good mood improved after 6-9 weeks. Positive effects on self-confidence appeared between 3-6 weeks and on fatigue after 9-12 weeks.

Conclusion: Insight into the emergence of effects may be useful information for the patient and for the attending physician in monitoring clinical effects of testosterone treatment of hypogonadal men.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Affect / drug effects*
  • Androgens / administration & dosage*
  • Androgens / metabolism
  • Androgens / therapeutic use
  • Humans
  • Hypogonadism / drug therapy*
  • Male
  • Prospective Studies
  • Sexuality / drug effects*
  • Surveys and Questionnaires
  • Testosterone / administration & dosage*
  • Testosterone / metabolism
  • Testosterone / therapeutic use
  • Time Factors


  • Androgens
  • Testosterone