doi: 10.1042/BST0371385.
Spare respiratory capacity, oxidative stress and excitotoxicity
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- PMID: 19909281
- DOI: 10.1042/BST0371385
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Spare respiratory capacity, oxidative stress and excitotoxicity
Biochem Soc Trans.
2009 Dec.
Abstract
Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
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