Eosinophilic airway inflammation during exacerbation of asthma and its treatment with inhaled corticosteroid

Am Rev Respir Dis. 1991 Feb;143(2):423-7. doi: 10.1164/ajrccm/143.2.423.


We have compared the inflammatory changes in the bronchial mucosa and the increase in the airway hyperresponsiveness in an asthmatic patient during the deterioration of symptoms. A striking increase in the number of bronchial epithelial eosinophils was associated with an increase in both airway hyperresponsiveness and asthma symptoms. During 16 wk of treatment with the inhaled corticosteroid, budesonide, the patient's clinical status and airway hyperresponsiveness improved. This was accompanied by an improvement in the ultrastructure of bronchial mucosa and a decrease in the number of epithelial eosinophils.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Asthma / complications*
  • Asthma / physiopathology
  • Biopsy
  • Bronchi / pathology
  • Bronchi / physiopathology
  • Bronchitis / complications*
  • Bronchitis / drug therapy
  • Bronchitis / pathology
  • Forced Expiratory Volume
  • Humans
  • Male
  • Middle Aged
  • Mucous Membrane / pathology
  • Pulmonary Eosinophilia / complications*
  • Pulmonary Eosinophilia / drug therapy


  • Adrenal Cortex Hormones