Voltage-sensitive dye imaging: Technique review and models

J Physiol Paris. Jan-Mar 2010;104(1-2):40-50. doi: 10.1016/j.jphysparis.2009.11.009. Epub 2009 Nov 10.


In this review, we present the voltage-sensitive dye imaging (VSDI) method. The possibility offered for in vivo (and in vitro) brain imaging is unprecedented in terms of spatial and temporal resolution. However, the unresolved multi-component origin of the optical signal encourages us to perform a detailed analysis of the method limitation and the existing models. We propose a biophysical model at a mesoscopic scale in order to understand and interpret this signal.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biophysics
  • Brain / cytology
  • Brain / physiology*
  • Brain Mapping*
  • Models, Biological*
  • Neural Pathways / physiology
  • Neuroglia / cytology
  • Neuroglia / physiology
  • Neurons / cytology
  • Neurons / physiology
  • Nonlinear Dynamics
  • Signal Processing, Computer-Assisted
  • Voltage-Sensitive Dye Imaging / instrumentation
  • Voltage-Sensitive Dye Imaging / methods*