Polymyositis presenting with cardiac manifestations: Report of two cases and review of the literature

Clin Neurol Neurosurg. 2010 Feb;112(2):160-3. doi: 10.1016/j.clineuro.2009.10.007. Epub 2009 Nov 11.


We report two patients with severe cardiac manifestations at the time of the initial presentation of polymyositis. Both cases are unusual in that they presented with predominant cardiac disturbances, associated with muscle weakness. One patient had a typical clinical syndrome of congestive heart failure, and the second mimicked an acute myocardial infarction in which coronary angiography was normal. From our cases, we can emphasize that aside from characteristic symmetrical proximal muscle weakness, the clinical features of polymyositis may also include cardiac complications.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Arrhythmia Agents / therapeutic use
  • Female
  • Heart Failure / diagnosis
  • Heart Failure / drug therapy
  • Heart Failure / etiology*
  • Humans
  • Male
  • Mexiletine / therapeutic use
  • Muscle, Skeletal / physiopathology
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / etiology*
  • Nausea / etiology
  • Polymyositis / complications
  • Polymyositis / diagnosis*
  • Polymyositis / physiopathology
  • Vomiting / etiology


  • Anti-Arrhythmia Agents
  • Mexiletine