Telomeric armor: the layers of end protection

J Cell Sci. 2009 Nov 15;122(Pt 22):4013-25. doi: 10.1242/jcs.050567.

Abstract

The linear nature of eukaryotic chromosomes necessitates protection of their physical ends, the telomeres, because the DNA-repair machinery can misconstrue the ends as double-stranded DNA breaks. Thus, protection is crucial for avoiding an unwarranted DNA-damage response that could have catastrophic ramifications for the integrity and stability of the linear genome. In this Commentary, we attempt to define what is currently understood by the term ;telomere protection'. Delineating the defining boundaries of chromosome-end protection is important now more than ever, as it is becoming increasingly evident that, although unwanted DNA repair at telomeres must be avoided at all costs, the molecular players involved in recognition, signaling and repair of DNA damage might also serve to protect telomeres.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Chromosomal Instability
  • DNA Damage
  • DNA Repair
  • Epigenesis, Genetic
  • Genome
  • Humans
  • Mice
  • Nucleic Acid Conformation*
  • Signal Transduction
  • Telomere* / chemistry
  • Telomere* / genetics
  • Telomere-Binding Proteins / genetics
  • Telomere-Binding Proteins / metabolism

Substances

  • Telomere-Binding Proteins