Immunohistochemical profile of human pancreatic pacinian corpuscles

Pancreas. 2010 Apr;39(3):403-10. doi: 10.1097/MPA.0b013e3181bc0372.


Objectives: To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.

Methods: We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins.

Results: Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile.

Conclusions: Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Sensing Ion Channels
  • Adult
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels / metabolism
  • Glial Fibrillary Acidic Protein / metabolism
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mucin-1 / metabolism
  • Nerve Tissue Proteins / metabolism
  • Pacinian Corpuscles / metabolism*
  • Pacinian Corpuscles / ultrastructure
  • Pancreas / metabolism*
  • Pancreas / ultrastructure
  • Receptor, trkB / metabolism
  • Receptors, Growth Factor / metabolism
  • Sensory Receptor Cells / metabolism


  • ASIC2 protein, human
  • Acid Sensing Ion Channels
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Glial Fibrillary Acidic Protein
  • Mucin-1
  • Nerve Tissue Proteins
  • Receptors, Growth Factor
  • Receptor, trkB