Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion

Kidney Int. 2009 Dec;76(11):1125-7. doi: 10.1038/ki.2009.352.

Abstract

Advanced oxidation protein products (AOPPs), a protein biomarker of increased oxidative stress, are elevated in uremic patients. Zhou et al. demonstrate that chronic administration of AOPPs induces podocyte apoptosis and proteinuria in normal rats via a cascade of signaling events. This study for the first time establishes a causative link between oxidative stress and podocyte depletion and could have broad implications in our understanding of the pathogenic mechanism of proteinuria.

Publication types

  • Comment

MeSH terms

  • Animals
  • Oxidative Stress*
  • Podocytes / physiology*
  • Proteins / metabolism*
  • Rats

Substances

  • Proteins