Anhydrous hydration of nitriles to amides using aldoximes as the water source

Jinwoo Lee; Min Kim; Sukbok Chang; Hee-Yoon Lee

doi:10.1021/ol902309z

Anhydrous hydration of nitriles to amides using aldoximes as the water source

Org Lett. 2009 Dec 17;11(24):5598-601. doi: 10.1021/ol902309z.

Authors

Jinwoo Lee¹, Min Kim, Sukbok Chang, Hee-Yoon Lee

Affiliation

¹ Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.

PMID: 19911824
DOI: 10.1021/ol902309z

Abstract

Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.