Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid

Clin Infect Dis. 2009 Dec 15;49(12):1946-9. doi: 10.1086/648447.


The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Adult
  • Female
  • Herpesvirus 8, Human / isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • RNA, Viral / analysis
  • Sarcoma, Kaposi / drug therapy*
  • Valproic Acid / therapeutic use*


  • RNA, Viral
  • Valproic Acid