Metachronous testicular teratoma, testicular seminoma and papillary thyroid carcinoma occurring in a single individual: a report of two unrelated cases

Eur J Cancer Care (Engl). 2010 Sep;19(5):701-2. doi: 10.1111/j.1365-2354.2009.01097.x. Epub 2009 Nov 11.


We describe two unrelated men who both developed teratomas in one testis followed by seminomas in the contralateral testis followed by papillary thyroid carcinomas. Neither man had a family history of cancers. Although random occurrence is possible, genetic predisposition and/or environmental influence would seem a likely explanation for this previously unreported combination of tumours.

MeSH terms

  • Adult
  • Carcinoma, Papillary / pathology*
  • Carcinoma, Papillary / therapy
  • Humans
  • Male
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Multiple Primary / therapy
  • Seminoma / pathology*
  • Seminoma / therapy
  • Teratoma / pathology*
  • Teratoma / therapy
  • Testicular Neoplasms / pathology*
  • Testicular Neoplasms / therapy
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / therapy
  • Treatment Outcome
  • Young Adult