Evidence against involvement of endorphins in sexual arousal and orgasm in man

Arch Gen Psychiatry. 1977 Oct;34(10):1179-80. doi: 10.1001/archpsyc.1977.01770220061006.


In a double-blind study, intravenous injection of naloxone, at a dose sufficient to saturate the opiate (endorphin) receptors, had no effect on sexual arousal, penile erection, ejaculation, or orgasm in a human subject. Apparently, endorphins are not involved in these phenomena.

Publication types

  • Case Reports
  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Endorphins / physiology*
  • Humans
  • Libido / physiology*
  • Male
  • Naloxone / pharmacology
  • Orgasm / physiology*
  • Receptors, Opioid / drug effects
  • Self-Assessment


  • Endorphins
  • Receptors, Opioid
  • Naloxone