Association study of the SLC25A12 gene and autism in Han Chinese in Taiwan

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):189-92. doi: 10.1016/j.pnpbp.2009.11.004. Epub 2009 Nov 10.

Abstract

Purpose: Autism is a childhood-onset neurodevelopmental disorder with a strong genetic component in its etiology. Several studies reported that the solute carrier family 25 member A12 (SLC25A12) gene was associated with autism. This study aimed to replicate this finding in a Han Chinese sample from Taiwan using a population-based case-control approach.

Methods: We genotyped two single nucleotide polymorphisms (SNPs, rs2056202 and rs2292813) of the SLC25A12 gene that were previously reported to be associated with autism in 465 patients (402 males and 63 females) and 450 control subjects (227 males and 223 females) from Taiwan. Differences in the genotype, allele, and haplotype frequencies between the two groups were compared.

Results: We found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls.

Conclusions: Our data do not support that the SLC25A12 gene is associated with autism in our population. The discrepant results of other studies may come from the clinical heterogeneity of patients recruited for studies, or the genetic heterogeneity of autism in different populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asians / ethnology*
  • Autistic Disorder / genetics*
  • Case-Control Studies
  • Child
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study / methods
  • Genotype
  • Humans
  • Male
  • Mitochondrial Membrane Transport Proteins / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Taiwan

Substances

  • Mitochondrial Membrane Transport Proteins
  • SLC25A12 protein, human