Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions

Alcohol. 2009 Nov;43(7):509-19. doi: 10.1016/j.alcohol.2009.01.002.


This article summarizes the proceedings of a symposium that was presented at a conference entitled "Alcoholism and Stress: A Framework for Future Treatment Strategies." The conference was held in Volterra, Italy on May 6-9, 2008 and this symposium was chaired by Jeff L. Weiner. The overall goal of this session was to review recent findings that may shed new light on the neurobiological mechanisms that underlie the complex relationships between stress, anxiety, and alcoholism. Dr. Danny Winder described a novel interaction between D1 receptor activation and the corticotrophin-releasing factor (CRF) system that leads to an increase in glutamatergic synaptic transmission in the bed nucleus of the stria terminalis. Dr. Marisa Roberto presented recent data describing how protein kinase C epsilon, ethanol, and CRF interact to alter GABAergic inhibition in the central nucleus of the amygdala. Dr. Jeff Weiner presented recent advances in our understanding of inhibitory circuitry within the basolateral amygdala (BLA) and how acute ethanol exposure enhances GABAergic inhibition in these pathways. Finally, Dr. Brian McCool discussed recent findings on complementary glutamatergic and GABAergic adaptations to chronic ethanol exposure and withdrawal in the BLA. Collectively, these investigators have identified novel mechanisms through which neurotransmitter and neuropeptide systems interact to modulate synaptic activity in stress and anxiety circuits. Their studies have also begun to describe how acute and chronic ethanol exposure influence excitatory and inhibitory synaptic communication in these pathways. These findings point toward a number of novel neurobiological targets that may prove useful for the development of more effective treatment strategies for alcohol use disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alcoholism / drug therapy
  • Alcoholism / etiology*
  • Alcoholism / physiopathology
  • Amygdala / drug effects
  • Amygdala / physiology
  • Animals
  • Anxiety / complications*
  • Anxiety / physiopathology
  • Corticotropin-Releasing Hormone / physiology
  • Ethanol / pharmacology
  • Humans
  • Protein Kinase C-epsilon / physiology
  • Receptors, GABA-B / physiology
  • Stress, Psychological / complications*
  • Stress, Psychological / physiopathology
  • Synaptic Transmission / drug effects
  • gamma-Aminobutyric Acid / metabolism


  • Receptors, GABA-B
  • Ethanol
  • gamma-Aminobutyric Acid
  • Corticotropin-Releasing Hormone
  • PRKCE protein, human
  • Protein Kinase C-epsilon

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