Stimulated neutrophil locomotion: chemokinesis and chemotaxis

Arch Pathol Lab Med. 1977 Oct;101(10):509-13.

Abstract

All leukocytes are capable of responding chemotactically (oriented locomotion) and chemokinetically (stimulated nondirected or random locomotion) to a variety of chemical agents. A brief review of the in vitro and in vivo methods of studying neutrophil movement and our present knowledge of chemotactic factors is presented as well as a discussion on the mechanisms of stimulated movement. Two clinically important instances of defects in neutrophil movement, ie, the Chédiak-Higashi syndrome and a case of actin dysfunction, are herein described.

Publication types

  • Review

MeSH terms

  • Ascorbic Acid / pharmacology
  • Calcium / metabolism
  • Cell Movement
  • Chediak-Higashi Syndrome / blood
  • Chemotaxis, Leukocyte*
  • Complement C3 / pharmacology
  • Complement C5 / pharmacology
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism
  • Cytological Techniques
  • Cytoskeleton
  • Humans
  • Inflammation
  • Kallikreins / pharmacology
  • Lysosomes / ultrastructure
  • Microtubules
  • Neutrophils / physiology*
  • Neutrophils / ultrastructure
  • Oligopeptides / pharmacology
  • Plasminogen Activators / pharmacology
  • Receptors, Drug
  • Skin Window Technique
  • Sodium / metabolism
  • Structure-Activity Relationship

Substances

  • Complement C3
  • Complement C5
  • Oligopeptides
  • Receptors, Drug
  • Sodium
  • Cyclic AMP
  • Kallikreins
  • Plasminogen Activators
  • Cyclic GMP
  • Ascorbic Acid
  • Calcium