Mucin-interacting proteins: from function to therapeutics

Trends Biochem Sci. 2010 Apr;35(4):236-45. doi: 10.1016/j.tibs.2009.10.003. Epub 2009 Nov 11.


Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Humans
  • Mucins / antagonists & inhibitors*
  • Mucins / metabolism*
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism*
  • Protein Binding / drug effects
  • Protein Structure, Tertiary
  • Transcription Factors / metabolism
  • Wnt Proteins / metabolism


  • Mucins
  • Transcription Factors
  • Wnt Proteins