Effect of motilin on gastric emptying in patients with diabetic gastroparesis

Diabetes Care. 1991 Jan;14(1):65-8. doi: 10.2337/diacare.14.1.65.


Objectives: Because disturbances of gastric emptying are a serious complication in insulin-dependent diabetic subjects with regard to the maintenance of good metabolic control, we wanted to assess the effectiveness of motilin as a potential treatment for gastric emptying disturbances.

Research design and methods: The intestinal hormone motilin has been shown to accelerate gastric emptying in healthy subjects. Therefore, we examined the effect of intravenous motilin on gastric emptying of a 99mTc colloid-labeled semisolid test meal in 9 insulin-dependent diabetic patients with diabetic gastroparesis. All patients had a significantly delayed gastric emptying rate compared with a group of 11 healthy control subjects.

Results: During the infusion of motilin, gastric emptying was accelerated, and it was no longer significantly different from control values.

Conclusions: These data demonstrate that motilin and related compounds such as erythromycin derivatives could be useful for the treatment of disturbed gastric emptying in diabetic subjects.

MeSH terms

  • Adult
  • Aged
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Female
  • Food
  • Gastric Emptying / drug effects*
  • Gastrointestinal Transit / drug effects
  • Humans
  • Male
  • Middle Aged
  • Motilin / pharmacology*
  • Paralysis / etiology
  • Paralysis / physiopathology*
  • Stomach Diseases / etiology
  • Stomach Diseases / physiopathology*
  • Technetium Tc 99m Sulfur Colloid


  • Motilin
  • Technetium Tc 99m Sulfur Colloid