Effective desensitization to imiglucerase in a patient with type I Gaucher disease

J Pediatr. 2009 Dec;155(6):940-1. doi: 10.1016/j.jpeds.2009.05.033.

Abstract

We describe a child who had anaphylactic hypersensitivity to imiglucerase therapy for Gaucher disease. Treatment was stopped and symptoms returned. After immune desensitization to imiglucerase using a rush protocol, the patient was able to resume treatment and has not had further hypersensitivity complications to date.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced
  • Anaphylaxis / diagnosis
  • Anaphylaxis / therapy*
  • Child
  • Desensitization, Immunologic*
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology
  • Drug Hypersensitivity / therapy*
  • Gaucher Disease / drug therapy*
  • Gaucher Disease / immunology
  • Glucosylceramidase / administration & dosage*
  • Glucosylceramidase / adverse effects
  • Humans
  • Male

Substances

  • Glucosylceramidase
  • imiglucerase