Dendritic cell subsets in primary and secondary T cell responses at body surfaces

Nat Immunol. 2009 Dec;10(12):1237-44. doi: 10.1038/ni.1822. Epub 2009 Nov 16.


We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses. Our major focus is on new developments in the understanding of immunity to infections of the skin and lung, which are crucial entry points for a variety of infectious pathogens. Initially we describe a diverse network of dendritic cell subsets, but then we argue for a more generalized model of reduced complexity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Humans
  • Pneumonia / immunology*
  • Skin Diseases, Infectious / immunology*
  • T-Lymphocytes / immunology*