The purpose of this paper was to explicate an initial conceptual model that is amenable to testing and guiding anti-stigma interventions with adolescents. Multidisciplinary research and theoretical articles were reviewed and a conceptual model was developed. The conceptual model can guide anti-stigma interventions and should undergo testing and refinement in the future to reflect scientific advances in stigma reduction among adolescents. Use of a conceptual model enhances empirical evaluation of anti-stigma interventions, yielding a casual explanation for the intervention effects and enhancing clinical applicability of interventions across settings.