Clinical applications for the use of enzymatic debriding ointment and broad-spectrum bacteriostatic foam dressing

J Wound Ostomy Continence Nurs. 2009 Nov-Dec;36(6 Suppl):S17-24. doi: 10.1097/WON.0b013e3181bfdacc.


The optimal management of a chronic, nonhealing wound is challenging to experienced and novice clinicians alike. Treatment must be individualized, but principles of wound bed preparation, including debridement of necrotic tissue, maintenance of moisture in the wound, and prevention of bacterial overgrowth, guide the management of nonhealing wounds caused by a variety of different etiologies. This article summarizes our experiences with 2 products, collagenase ointment and crystal violet/methylene blue-impregnated foam, in the treatment of 3 nonhealing wounds.

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage*
  • Bandages*
  • Chronic Disease
  • Clostridium histolyticum*
  • Debridement / methods*
  • Female
  • Humans
  • Male
  • Microbial Collagenase / administration & dosage*
  • Middle Aged
  • Ointments
  • Wound Healing
  • Wound Infection / prevention & control*
  • Wounds and Injuries / microbiology
  • Wounds and Injuries / therapy*


  • Anti-Bacterial Agents
  • Ointments
  • Microbial Collagenase