Collagenase for enzymatic debridement: a systematic review

J Wound Ostomy Continence Nurs. 2009 Nov-Dec;36(6 Suppl):S4-11. doi: 10.1097/WON.0b013e3181bfdf83.


Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice. This systematic review summarizes and ranks evidence concerning the safety and efficacy of the selective enzymatic debriding agent collagenase. Studies were identified comparing collagenase to inactive (sham) ointment and to alternate techniques for debridement including autolytic and surgical. A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Burns / therapy*
  • Collagenases / administration & dosage
  • Collagenases / adverse effects
  • Collagenases / therapeutic use*
  • Debridement / methods*
  • Humans
  • Ointments
  • Safety
  • Skin Ulcer / therapy*


  • Ointments
  • Collagenases