Pitfalls in diagnostic hematopathology -- Part II

Int J Clin Exp Pathol. 2009 Sep 10;3(1):39-46.


The overlapping features of malignant lymphomas create a diagnostic "grey zone" , and lead to the invention of "grey zone lymphomas". There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping features of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte rich large B-cell lymphoma; 4) Lymphomas with overlapping features of Hodgkin lymphoma, anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphoma (PTCL); 5) T-cell classical Hodgkin lymphoma and ALCL-HL. The second review of this series will be dedicated to discussion of the "grey zone" features of the lymphomas and how to narrow down the "grey zone" between those lymphomas.

Keywords: Burkitt lymphoma; DLBCL; Hodgkin lymphoma; diagnostic pitfalls; grey zone lymphoma.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Diagnostic Errors / prevention & control*
  • Hodgkin Disease / classification
  • Hodgkin Disease / diagnosis*
  • Humans
  • Lymphoma, Non-Hodgkin / classification
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Pathology, Clinical / education
  • Pathology, Clinical / standards
  • World Health Organization