Recent insights into host-pathogen interactions from Dictyostelium

Cell Microbiol. 2010 Mar;12(3):283-91. doi: 10.1111/j.1462-5822.2009.01413.x. Epub 2009 Nov 16.


To protect themselves from predation by amoebae and protozoa in the natural environment, some bacteria evolved means of escaping killing. The same mechanisms allow survival in mammalian phagocytes, producing opportunistic human pathogens. The social amoeba Dictyostelium discoideum is a powerful system for analysis of conserved host-pathogen interactions. This report reviews recent insights gained for several bacterial pathogens using Dictyostelium as host.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / growth & development*
  • Cytoplasm / microbiology
  • Dictyostelium / microbiology*
  • Host-Pathogen Interactions*
  • Humans