Sustainable effects on suicidality were found for the Nuremberg alliance against depression

Eur Arch Psychiatry Clin Neurosci. 2010 Aug;260(5):401-6. doi: 10.1007/s00406-009-0088-z. Epub 2009 Nov 17.


During an intense four-level community-based intervention program conducted in Nuremberg (490,000 inhabitants) in 2001 and 2002 [Nuremberg Alliance Against Depression (NAD)], the number of suicidal acts (main outcome completed + attempted suicides) had dropped significantly (-21.7%), a significant effect compared with the baseline year and the control region (Wuerzburg, about 290,000 inhabitants). To assess the sustainability of the intervention effects the number of suicidal acts was assessed in the follow-up year (2003), after the termination of the 2-year intervention. Also, in the follow-up year (2003), the reduction in suicidal acts compared with the baseline year in Nuremberg (2000 vs. 2003: -32.4%) was significantly larger than that in the control region (P = 0.0065). The reduction was even numerically larger than that of the intervention years (2001, 2002). Thus, 1 year after the end of the main intervention, preventive effects on suicidality of the NAD remain at least stable. The four-level intervention concept appears to be cost-effective and is presently implemented in many European regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Depression / drug therapy*
  • Depression / epidemiology
  • Depression / psychology*
  • Female
  • Germany / epidemiology
  • Humans
  • Longitudinal Studies
  • Male
  • Regression Analysis
  • Retrospective Studies
  • Suicide / statistics & numerical data*
  • Suicide Prevention*
  • Treatment Outcome


  • Antidepressive Agents