8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: A Potent and Selective Adenosine A1 Antagonist With Renal Protective and Diuretic Activities

J Med Chem. 1991 Jan;34(1):466-9. doi: 10.1021/jm00105a072.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Diuretics / chemical synthesis*
  • Indicators and Reagents
  • Kidney / drug effects
  • Kidney / physiology*
  • Kidney Function Tests
  • Kinetics
  • Male
  • Molecular Structure
  • Rats
  • Rats, Inbred Strains
  • Receptors, Purinergic / drug effects*
  • Receptors, Purinergic / metabolism
  • Structure-Activity Relationship
  • Xanthines / chemical synthesis*
  • Xanthines / chemistry
  • Xanthines / pharmacology

Substances

  • Diuretics
  • Indicators and Reagents
  • Receptors, Purinergic
  • Xanthines
  • 8-(dicyclopropylmethyl)-1,3-dipropylxanthine