Kidney injury molecule-1 in renal disease

J Pathol. 2010 Jan;220(1):7-16. doi: 10.1002/path.2642.


Kidney injury molecule-1 (KIM-1) is a marker for renal proximal tubular damage, the hallmark of virtually all proteinuric, toxic and ischaemic kidney diseases. KIM-1 has gained increasing interest because of its possible pathophysiological role in modulating tubular damage and repair. In this respect, it is interesting that the best biomarkers often turn out to be important in modulation of damage and some even become therapeutic targets. The emphasis of this review is on structural and biochemical aspects of KIM-1, its expression pattern and its pathophysiological role in renal disease. We also discuss the prognostic impact of KIM-1 in relation to urinary protein excretion. Glomerular (proteinuria) and interstitial markers (KIM-1) might have independent prognostic impact and so may provide independent treatment targets. Finally, the potential of KIM-1 as biomarker of renal damage, as a predictor of renal function decline and its perspectives for monitoring therapy response, are discussed.

Publication types

  • Review

MeSH terms

  • Biomarkers / metabolism
  • Drug Monitoring / methods
  • Hepatitis A Virus Cellular Receptor 1
  • Humans
  • Kidney Diseases / diagnosis
  • Kidney Diseases / drug therapy
  • Kidney Diseases / metabolism*
  • Kidney Tubules / metabolism
  • Membrane Glycoproteins / metabolism*
  • Membrane Glycoproteins / physiology
  • Phagocytosis / physiology
  • Prognosis
  • Receptors, Virus / metabolism*
  • Receptors, Virus / physiology


  • Biomarkers
  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • Membrane Glycoproteins
  • Receptors, Virus