In vitro and in vivo biological activity of PEDF against a range of tumors

Expert Opin Ther Targets. 2009 Dec;13(12):1429-38. doi: 10.1517/14728220903307475.

Abstract

Background: Pigment epithelium-derived factor (PEDF) is an emerging anti-cancer agent that targets both tumor tissue and its supporting vasculature. These direct and indirect effects of PEDF have been examined in vitro and in vivo for a range of malignancies.

Objective: This review seeks to present PEDF as a potential anti-cancer agent with applications across multiple malignancies. We refer closely to experimental methodology whilst still highlighting the clinical significance of PEDF in cancer, drawing on biological findings in vitro and in vivo.

Methods: A Pubmed database search was performed limiting the scope of this discussion paper mainly to PEDF's biological role in cancer, specifically lung, breast, prostatic, ovarian and pancreatic carcinomas, melanoma, glioma and osteosarcoma.

Conclusions: The biological roles of PEDF are diverse and multidimensional. As an anti-cancer agent, PEDF has great potential as a focused anti-neoplastic therapy against a variety of tumor types.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Eye Proteins / pharmacology*
  • Eye Proteins / physiology*
  • Female
  • Humans
  • Male
  • Neoplasms / drug therapy*
  • Nerve Growth Factors / pharmacology*
  • Nerve Growth Factors / physiology*
  • Serpins / pharmacology*
  • Serpins / physiology*

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Eye Proteins
  • Nerve Growth Factors
  • Serpins
  • pigment epithelium-derived factor