Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target

Int J Neurosci. 2009;119(9):1399-418. doi: 10.1080/00207450802324564.


Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Adhesion / physiology*
  • Cell Count
  • Choroid Plexus / drug effects
  • Choroid Plexus / metabolism*
  • Deep Brain Stimulation*
  • Electrodes, Implanted
  • Encephalomyelitis, Autoimmune, Experimental / pathology
  • Encephalomyelitis, Autoimmune, Experimental / prevention & control*
  • Female
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Intercellular Adhesion Molecule-1 / biosynthesis*
  • Male
  • Matrix Metalloproteinase 2 / biosynthesis*
  • Myelin Sheath / metabolism
  • Oligodendroglia / pathology
  • Rats
  • Third Ventricle / metabolism
  • Up-Regulation
  • Vascular Cell Adhesion Molecule-1 / biosynthesis*


  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • Matrix Metalloproteinase 2