Salivary gland tumours as second neoplasms: two cases and literature review

J Laryngol Otol. 2010 May;124(5):577-80. doi: 10.1017/S0022215109991526. Epub 2009 Nov 19.


Objectives: Patients who survive malignant tumours have an increased risk of second neoplasms, including those of the salivary glands. Mucoepidermoid carcinoma of the parotid gland is by far the most common type of second salivary gland tumour; other types have rarely been reported. We describe here two patients with a second tumour of the salivary glands.

Case reports: The first patient was a 22-year-old woman with a low grade mucoepidermoid carcinoma of the parotid gland, which developed 21 years after completion of chemoradiotherapy for acute lymphoblastic leukaemia. The second patient was a 40-year-old woman with an epithelial-myoepithelial carcinoma of the buccal mucosa, which arose 11 years after treatment for two malignant neoplasms - retroperitoneal liposarcoma and squamous cell carcinoma of the uterine cervix.

Conclusions: It is mandatory that survivors of cancer should be monitored carefully, so that the complications related to their previous disease and therapy are detected early and managed properly.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Carcinoma, Mucoepidermoid / etiology*
  • Carcinoma, Mucoepidermoid / pathology
  • Female
  • Humans
  • Neoplasms, Second Primary / etiology*
  • Neoplasms, Second Primary / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Salivary Gland Neoplasms / etiology*
  • Salivary Gland Neoplasms / pathology
  • Young Adult