Acting out of character: regulatory roles of nuclear pore complex proteins

Dev Cell. 2009 Nov;17(5):617-25. doi: 10.1016/j.devcel.2009.10.015.


Nuclear pore complexes (NPCs) mediate all selective bidirectional transport between the nucleus and the cytoplasm. Additional functions for NPCs and their constituent proteins (nucleoporins) are emerging, some independent of classical transport. Specifically, enzymatic activities at the NPC regulate nucleocytoplasmic transport and use the NPC as a regulatory scaffold. Also, nucleoporins may regulate gene expression by contacting chromatin. Discriminating between effects on transport, scaffolding, and gene expression is a major challenge in understanding the role of the NPC in signaling and development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Nucleus / metabolism
  • Cytoskeleton / metabolism
  • Gene Expression Regulation, Developmental*
  • Humans
  • Nuclear Pore Complex Proteins / metabolism*
  • Nuclear Pore Complex Proteins / ultrastructure
  • Signal Transduction


  • Nuclear Pore Complex Proteins