Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

Nature. 1991 Jan 31;349(6308):388-93. doi: 10.1038/349388a0.


Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CDC2 Protein Kinase / physiology*
  • Cell Cycle*
  • DNA Replication
  • Fungal Proteins / metabolism
  • Mitosis*
  • Mutation
  • Nitrogen / metabolism
  • S Phase*
  • Schizosaccharomyces / cytology*
  • Schizosaccharomyces / genetics


  • Fungal Proteins
  • CDC2 Protein Kinase
  • Nitrogen